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Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls.

Thambirajah AA et al.

Clinical and Investigative Medicine (Medecine Clinique et Experimentale). 2008 Dec 01; 31(6):E319-27

PMID: 19032901

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13 Jul 2009
Yves Jammes
Yves Jammes

1039480190596147

Exercise-induced oxidative stress is present in all individuals, including the healthy ones. In normal subjects, the enhanced production of reactive oxygen species (ROS) is counterbalanced by the activation of intracellular and blood antioxidants. In this study, Thambirajah and co-workers report a defective adaptive response to oxidative stress in patients with chronic fatigue syndrome (CFS). Heat shock proteins (HSPs) play key roles in this adaptive response, which protects muscle cells against the deleterious effects of an excessive ROS production. The authors show that the expression of HSPs is markedly attenuated for a 7-day period following a standardized treadmill exercise. These data were confirmed in a recent publication by myself and colleagues {1}. The lack of HSP response explains why CFS patients present an exacerbated ROS production after cycling exercise (please see {2} in which I am listed as an author), which might explain their altered muscle function. Because in a majority of CFS patients chronic muscle fatigue occurs after a prolonged period of physical hyperactivity, this raises the question of a reduced expression of HSP inductors after repetitive stimulation and thus of possible deleterious effects of repetitive strenuous exercise bouts.

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