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Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.

Sarkar S et al.

Neurotoxicology. 2018 Jan; 64:204-218

https://doi.org/10.1016/j.neuro.2017.05.009PMID: 28539244

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01 Jun 2017
Michael Aschner
Michael Aschner

8042742731069225

The manuscript provides additional proof for the susceptibility of dopaminergic neurons to manganese (Mn), as well as the critical role astrocytes play in mediating this metal's neurotoxicity. The study also highlights the need for further understanding the role in neuronal inflammation in mediating Mn-induced neurotoxicity, and also suggests that microglia are likely to partner in the process. Accordingly, future studies should focus on the tripartite involvement of astrocytes, microglia and neurons (and likely also endothelial cells of the blood-brain barrier) in mediating the dopaminergic neurodegeneration associated with Mn exposure, either orally or nasally, secondary to occupational exposures.

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